Welcome to Protein WISDOM at the CASL in Princeton

Workbench for In Silico De novo design Of bioMolecules

Protein WISDOM is a workbench that allows the academic community to make use of our de novo protein design framework. The framework is divided into two stages: a sequence selection stage and a validation stage. The sequence selection stage designs novel protein and peptide sequences based upon a rigid or flexible design template uploaded by the user. Once sequence are generated, they can be validated by either fold specificity or approximate binding affinity. Fold specificity is a measure of how well the designed sequence adopts the template fold while approximate binding affinity is a measure of how well the designed sequence binds to a given protein target. To learn about the methodology behind the workbench, please view our Publications.

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